1.December 1994 - [URL="http://www.lookchem.com/Lamotrigine/"]Lamotrigine[/URL] was approved for the treatment of partial seizures.
2.August 1998 - for use as adjunctive treatment of Lennox-Gastaut syndrome in pediatric and adult patients, new dosage form: chewable dispersible tablets.
3.December 1998 - for use as monotherapy for treatment of partial seizures in adult patients when converting from a single enzyme-inducing anti-epileptic drug (EIAED).
4.January 2003 - for use as adjunctive therapy for partial seizures in pediatric patients as young as 2 years of age.
5.June 2003 - Lamotrigine approved for maintenance treatment of Bipolar I disorder; the first since lithium.
6.January 2004 - for use as monotherapy for treatment of partial seizures in adult patients when converting from the anti-epileptic drug valproate (including valproic acid (Depakene); sodium valproate (Epilim) and divalproex sodium (Depakote)).